by Natasha Kyprianou (University of Kentucky, USA)

This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on analysis of data from existing clinical trials.

• The Prostate Gland Dynamics
• Apoptosis Signaling Pathways: Defined Routes to Eliminate Cancer Cells
• Androgen Receptor-Mediated Apoptosis: Significance in Development of Hormone Refractory Prostate Cancer
• Anoikis in Prostate Cancer Metastasis
• Novel Molecular Therapeutics for Targeting of Androgen-Independent Prostate Cancer
• Summary and Future Directions