edited by Martin Zacharias (Technische Universität München, Germany)

Table of Contents (31k)
Preface (41k)
Chapter 1: X-ray Study of Protein¨CProtein Complexes and Analysis of Interfaces (307k)

Given the immense progress achieved in elucidating protein–protein complex structures and in the field of protein interaction modeling, there is great demand for a book that gives interested researchers/students a comprehensive overview of the field. This book does just that. It focuses on what can be learned about protein–protein interactions from the analysis of protein–protein complex structures and interfaces. What are the driving forces for protein–protein association? How can we extract the mechanism of specific recognition from studying protein–protein interfaces? How can this knowledge be used to predict and design protein–protein interactions (interaction regions and complex structures)? What methods are currently employed to design protein–protein interactions, and how can we influence protein–protein interactions by mutagenesis and small-molecule drugs or peptide mimetics?

The book consists of about 15 review chapters, written by experts, on the characterization of protein–protein interfaces, structure determination of protein complexes (by NMR and X-ray), theory of protein–protein binding, dynamics of protein interfaces, bioinformatics methods to predict interaction regions, and prediction of protein–protein complex structures (docking and homology modeling of complexes, etc.) and design of protein–protein interactions. It serves as a bridge between studying/analyzing protein–protein complex structures (interfaces), predicting interactions, and influencing/designing interactions.

• X-ray Study of Protein–Protein Complexes and Analysis of Interfaces (J Janin)
• A Structural Perspective on Protein–Protein Interactions in Macromolecular Assemblies (R P Bahadur)
• Energetics of Protein–Protein Interactions (I Jelezarov)
• Kinetics of Biomacromolecular Complex Formation: Theory and Experiment (G V Pachov et al.)
• Evolutionary Trace of Protein Functional Determinants (O Lichtarge)
• Protein–Protein Docking (A Saladin & C Prevost)
• Data-driven Docking: Using External Information to Spark the Biomolecular Rendez-vous (A S J Melquiond & A M J J Bonvin)
• High-Resolution Protein–Protein Docking (N London & O Schueler-Furman)
• Scoring and Refinement of Predicted Protein–Protein Complexes (M Zacharias)
• Motif-medicated Protein Interactions and Their Role in Disease (H Dinkel & H Sticht)
• Prediction and Calculation of Protein–Protein Binding Affinities and Mutation Effects (S Fiorucci et al.)
• Small-molecule Inhibitors of Protein–Protein Interactions (T Berg)
• Protein Dynamics and Drug Design: The Role of Molecular Simulations (G Morra et al.)