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CHEMOGENOMICS
Knowledge-based Approaches to Drug Discovery
edited by Edgar Jacoby (Novartis Institutes for Biomedical Research, Switzerland)
In the post-genomic era, one of the key challenges for drug discovery is making optimal use of the comprehensive genomic data available after the elucidation of the human genome and others in order to identify effective new medicines. Addressing this challenge, chemogenomics aims to identify systematically all ligands and modulators for all the gene products expressed and allows the accelerated exploration of their biological function. The subject brings together diverse disciplines including chemistry, genetics, chemo- and bioinformatics, structural biology, and biological screening in phenotypic and target-based assays.
This book uniquely integrates reviews of the latest cutting-edge research by leaders in the various disciplines, providing a general, knowledge-centric overview of the different chemical, biological and informatics components. Unlike existing publications, the book focuses on how these disciplines interact efficiently for the rapid discovery of new targets and their effector molecules simultaneously. Examples of chemogenomics approaches pursued in academia as well as in biotech and pharmaceutical companies are also provided.
Contents:
- Small Molecules for Chemogenomics-based Drug Discovery (E Jacoby et
al.)
- Mapping the Chemogenomic Space (J Mestres)
- Natural Product Scaffolds and Protein Structure Similarity Clustering (PSSC) as Inspiration Sources for Compound Library Design in Chemogenomics and Drug Development (F J Dekker et al.)
- A Reductionist Approach to Chemogenomics in the Design of Drug Molecules and Focused Libraries (R Crossley & M Slater)
- In silico Screening of the Protein Structure Repertoire and of Protein Families (D Rognan)
- New Methods for Smilarity-based Virtual Screening (J Hert et al.)
- Structural Informatics: Chemogenomics In silico (D A Debe et al.)
- Construction of a Homogenous and Informative In vitro Profiling Database for Anticipating the Clinical Effects of Drugs (N Froloff et al.)
Readership: Undergraduate and graduate students, and researchers in molecular
pharmacology, pharmacy, medicinal chemistry, molecular and structural biology, drug discovery, genomics, bioinformatics.
| 220pp |
Pub. date: May 2006 |
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Copyright © 2008 Imperial College Press. All rights reserved.
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